Exosomes

Cellular Messengers of Precision Medicine

Exosomes, diminutive extracellular vesicles measuring approximately 30 to 150 nanometers in diameter, represent a burgeoning frontier in intercellular communication. Laden with a plethora of bioactive molecules, including proteins, nucleic acids (e.g., RNA and DNA), and lipids, these vesicles function as molecular couriers, facilitating the exchange of information among disparate cellular constituents.

 Exosomes, however, are not mere conduits of cellular communication, but wield regulatory authority over diverse cellular processes, including:

  • Immune modulation
  • Inflammation suppression
  • Apoptotic inhibition
  • Tissue fibrosis mitigation
  • Facilitation of tissue repair and regeneration.

Cumulative research underscores the multifaceted therapeutic potential of exosomes, and their promise as versatile tools in precision medicine interventions.

>>> Biomedicine

References

References for effectiveness on skin：

  1. Wu, Peipei et al. “HucMSC exosome-delivered 14-3-3ζ alleviates ultraviolet radiation-induced photodamage via SIRT1 pathway modulation.” Aging vol. 13,8 (2021): 11542-11563. doi:10.18632/aging.202851
  2. Oh, Myeongsik et al. “Exosomes Derived from Human Induced Pluripotent Stem Cells Ameliorate the Aging of Skin Fibroblasts.” International journal of molecular sciences vol. 19,6 1715. 9 Jun. 2018, doi:10.3390/ijms19061715
  3. Wu, Hao, et al. “Extracellular vesicles derived from human dermal fibroblast effectively ameliorate skin photoaging via miRNA-22-5p-GDF11 axis.” Chemical Engineering Journal 452 (2023): 139553.
  4. Ellistasari, Endra Yustin et al. “Exosomes Derived from Secretome Human Umbilical Vein Endothelial Cells (Exo-HUVEC) Ameliorate the Photo-Aging of Skin Fibroblast.” Clinical, cosmetic and investigational dermatology vol. 15 1583-1591. 8 Aug. 2022, doi:10.2147/CCID.S371330

References for effectiveness on hair follicles and scalp：